It is a well-known fact, that people who sweat abnormally experience social and personal difficulties in their lives. According to a new study published in the Archives of Dermatological Research, up to 75% of those who suffer from excessive sweating say that hyperhidrosis has a negative impact on their social life and emotional and mental health. The same research revealed the fact that the number of people affected by profuse perspiration is bigger than it was expected. About 4.8 % of the population has some kind of excessive sweating.
Fortunately, these times there are several ways how to treat this condition effectively. Qbrexza for excessive sweating comes to wide this list and offers an alternative to existing treatments. Since Qbrexza was approved by the FDA (U.S Food and drug administration) in June 2018, it belongs to completely new treatments of hyperhidrosis. The last method for dealing with excessive sweating approved by FDA was MiraDry in 2011.
What is Qbrexza?
Qbrexza is prescription medication in the form of wipes or towels intended for the topical treatment of axillary hyperhidrosis (excessive sweating underarms). It is developed and produced by the biopharmaceutical company Dermira Inc. These medicated wipes are packaged individually, and one cloth should be used for both underarms. Patients apply one cloth per day for both armpits to reduce profuse sweating.
Who Is It For?
Qbrexza was designed and intended for people who experience excessive sweating in armpits. This condition is called axillary hyperhidrosis, and it is probably the most common manifestation of excessive sweating. When sweating is limited to a certain body area, we talk about Primary focal hyperhidrosis. This condition has some typical characteristics.
Profuse sweating occurs only in some areas (mostly armpits, hands, feet or head) and it happens without an apparent cause. It means there is no underlying health problem or medicament triggering perspiration. Qbrexza is a reasonable solution for people who experience heavy and often underarm perspiration that dramatically disturbs normal life.
How does it work?
The active substance is glycopyrronium tosylate that belongs to anticholinergics. There are several anticholinergic oral medicaments used for suppressing symptoms of hyperhidrosis, but they often have side effects such as dry mouth or urinary retention. The difference between oral anticholinergic and Qbrexza is that Qbrexza is applied topically. The active ingredient comes to the body through the skin what minimizes the possible side effects.
The treatment works by blocking receptors responsible for sweat gland activation. It means, your nervous system sends a signal to your sweat glands, but glycopyrronium breaks this connection and prevent sweat producing.
What Is a Difference Between Qbrexza And Antiperspirants?
Over-the-counter antiperspirants are used for excessive sweating for a long time. You can get antiperspirant in pharmacies and online shops without a prescription. The main active substance is aluminium chloride, and the percentage of this ingredient varies from product to product (usually it is 10-20%). Topical application of aluminium chloride narrows the skin pores what makes them unable to release sweat. Practically it is chemical-mechanical protection working by blocking the sweat ducts.
On the other hand, Qbrexza doesn’t change anything about skin pores, but it prevents sweat glands from getting a “sweating signal” from the nervous system. Then, sweat glands even don’t know they should be activated.
What Are Risks and Possible Side Effects?
Every treatment of every condition has some possible side effects. Qbrexza belongs to a safe procedure with minimal side problems, and that’s why this treatment should be prescripted also to the children from 9 years. The side effects of Qbrexza are similar like other anticholinergic oral medicines, but due to topical application of Qbrexza cloths, these effects occur rarely. Possible side effects found from clinical trials are:
- dry mouth
- dilation of the pupils
- sore throat
- skin redness
- itching in the underarm area
- problems with urination
- blurred vision
- problems with control of your body temperature
The most common problems recorded during the treatment were dry mouth (in 16.9-24.2% of patients) and erythema – redness in the treated area (in 17% of patients). The trials have shown that using wipes were well-tolerated and most of the patients reported mild to moderate side effects.
There are some other possible difficulties as a contraindication linked to using certain medications. Before taking Qbrexza, it is needed to visit a physician and undergo an examination. The doctor can explore your health condition, see your health history and recognise possible risks or recommend another treatment.
What Your Dermatologist Need to Know
As we mentioned above, some health conditions can be worsened by using Qbrexza or other anticholinergic medicine. Patient with glaucoma, ulcerative colitis or Sjogren’s syndrome shouldn’t use Qbrexza.
During visiting a doctor, you should tell him/her if you have difficulties with prostate, bladder, kidney or if you have problems with passing urine. Also, pregnant women or women that plan to be pregnant should inform the doctor. He/she also needs to know all the medicine you take even over the counter medicines.
Medications With Possible Interindications
These medicaments can affect unwanted symptoms we mentioned above:
- Antipsychotics (Olanzapine, Haloperidol, Chlorpromazine,…)
- Antihistamines (Doxylamine, Promethazine, Cyproheptadine,…)
- Anticonvulsants (Carbamazepine,…)
- Antiemetics (Scopolamine,…)
- Topical ophthalmoplegic (Homatropine, Cyclopentolate,…)
The Qbrexza webpage has a section called online doctor where you can register, and after filling a questionnaire about your condition and sweating, some dermatologist will receive a notification about your case. There are about 300 online dermatologists in this system, and it works 24 hours 7 days a week. You will get a diagnostics and treatment plan very soon (usually within 24 hours). Check Online doctor now.
Is Qbrexza Effective?
The efficiency of Qbrexza was also investigated during clinical trials. Patients using wipes daily for four weeks recorded reducing their sweating by 25% to 30%, and sweat volume decreased by 50% and more. In the long run, more than 72% of participants experienced decreasing of excessive perspiration.
How to Apply Qbrexza Correctly?
Qbrexza cloth should be applied every 24 hours to clean and dry underarms. One cloth is used for both armpits. After the application, you should throw the used wipe and wash your hands properly. Never use wipes on irritated skin, because chemicals in wipes can worsen the irritation.
What Are Alternatives?
People who want to solve their problem with excessive underarm sweating have several treatment options:
1. Over-the-counter antiperspirant
Due to availability and relatively fast effects, using an over-the-counter antiperspirant is the most common way how to reduce underarm perspiration. Antiperspirant contains aluminium chloride that doesn’t allow sweat to reach the upper part of the skin. Many antiperspirants can be used for other sweaty parts of the body. You can get these products in pharmacies or online shops.
2. Prescribed antiperspirant
The difference between over-the-counter antiperspirant and prescribed antiperspirant is in the amount of active substance (mostly aluminium chloride). A doctor can recommend an antiperspirant with a high percentage of astringents after the examination of the patient.
We have already mentioned oral anticholinergic, that cut the connection between the nervous system and sweat glands. Using this treatment has to be considered by a dermatologist.
It is a popular and effective method that uses electrical current for affecting a function of sweat glands. In the case of axillary hyperhidrosis, an iontophoresis machine with two electrodes (for both armpits) are used for treatment. A doctor should perform iontophoresis, but it is also possible to buy a device for home treatment. Iontotherapy is mostly prefered for excessive sweating hands and feet.
Injections of botulinum toxin are also a very effective option on how to get rid of profuse underarm perspiration. The positive of botox is long lasting effects while negatives included higher price and possible side effects. Read more about botox here.
6. ETS Surgery
Endoscopic Thoracic Sympathectomy is a surgery when a surgeon destroys nerve paths in the affected area and stops the transmission of nerve signals from the spinal column to the sweat glands. This way is usually used for heavy cases of hyperhidrosis when other non-invasive treatments didn’t work enough.
Another possibility of how to reduce excessive sweating in armpits is using a microwave technology called MiraDry. Shortly, it is a device producing microwaves that are applied to the affected area. MiraDry also belongs to very effective and safe procedures.
Is Qbrexza for me?
Well, this is a difficult question, because the correct answer depends on many factors. If you belong to heavy sweaters who haven’t tried any treatment before, we recommend starting with over-the-counter antiperspirant. If the results aren’t satisfying, you can try Inototherapy because it is a non-invasive method using no chemicals. Anyway, visiting a doctor is always the safest way how to start with proper treatment.